BDBM247039 2-((1R,3aR, 6S,7R,7aS)-7- ((E)-2-(5-(2- cyanophenyl) pyridin-2- yl)vinyl)-5,5- difluoro- 1,6-dimethyl-3- oxooctahydro- isobenzofuran- 3a- yl)propanamide::US9701669, 7::US9701669, 8::US9701669, 9

SMILES CC(C(N)=O)[C@@]12CC(F)(F)[C@@H](C)[C@H](\C=C\c3ccc(cn3)-c3ccccc3C#N)[C@@H]1[C@@H](C)OC2=O

InChI Key InChIKey=FXKUUXSFWISISL-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 247039   

TargetSerine/threonine-protein kinase MARK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM247039(US9701669, 8 | 2-((1R,3aR, 6S,7R,7aS)-7- ((E)-2-(5...)
Affinity DataIC50: 4.43nMAssay Description:This assay measures the potency of the inventive compounds as PAR-1 receptor antagonists.Frozen HEK 293 Cells were plated in 384-well PDL coated plat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase MARK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM247039(US9701669, 8 | 2-((1R,3aR, 6S,7R,7aS)-7- ((E)-2-(5...)
Affinity DataIC50: 4.07nMAssay Description:This assay measures the potency of the inventive compounds as PAR-1 receptor antagonists.Frozen HEK 293 Cells were plated in 384-well PDL coated plat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase MARK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM247039(US9701669, 8 | 2-((1R,3aR, 6S,7R,7aS)-7- ((E)-2-(5...)
Affinity DataIC50: 11.3nMAssay Description:This assay measures the potency of the inventive compounds as PAR-1 receptor antagonists.Frozen HEK 293 Cells were plated in 384-well PDL coated plat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM247039(US9701669, 8 | 2-((1R,3aR, 6S,7R,7aS)-7- ((E)-2-(5...)
Affinity DataIC50: 3.91E+4nMpH: 7.4 T: 2°CAssay Description:Drug cardiac arrhythmia is an important safety concern for pharmaceutical development and health regulatory authorities. Blockade of heterologously-e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM247039(US9701669, 8 | 2-((1R,3aR, 6S,7R,7aS)-7- ((E)-2-(5...)
Affinity DataIC50: 2.63E+4nMpH: 7.4 T: 2°CAssay Description:Drug cardiac arrhythmia is an important safety concern for pharmaceutical development and health regulatory authorities. Blockade of heterologously-e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM247039(US9701669, 8 | 2-((1R,3aR, 6S,7R,7aS)-7- ((E)-2-(5...)
Affinity DataIC50: 5.97E+4nMpH: 7.4 T: 2°CAssay Description:Drug cardiac arrhythmia is an important safety concern for pharmaceutical development and health regulatory authorities. Blockade of heterologously-e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent