BDBM245537 US9428503, 67

SMILES CO[C@@H]1CC[C@H](C1)n1c2c(cnc3ccc(cc23)-c2ccc(OCCCN3CCCC3)nc2)n(C)c1=O

InChI Key InChIKey=QEOJMXMERFKIIJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 245537   

TargetSerine-protein kinase ATM(Human)
Astrazeneca

US Patent
LigandPNGBDBM245537(US9428503, 67)
Affinity DataIC50: 0.0525nMT: 2°CAssay Description:Assay a) HT29 cells (ECACC #85061109) were seeded into 384 well assay plates (Costar #3712) at a density of 3500 cells/well in 40 μl EMEM medium c...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
Astrazeneca

US Patent
LigandPNGBDBM245537(US9428503, 67)
Affinity DataIC50: 1.52E+4nMT: 2°CAssay Description:Assay b) HT29 cells (ECACC #85061109) were seeded into 384 well assay plates (Costar #3712) at a density of 6000 cells/well in 40 μl EMEM medium c...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM245537(US9428503, 67)
Affinity DataIC50: 2.85E+3nMT: 2°CAssay Description:Assay c) BT474 cells (human breast ductal carcinoma, ATCC HTB-20) were seeded into black 384 well plates (Costar, #3712) at a density of 5600 cells/w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Astrazeneca

US Patent
LigandPNGBDBM245537(US9428503, 67)
Affinity DataIC50: 996nMT: 2°CAssay Description:Assay d) MDA-MB-468 cells (human breast adenocarcinoma ##ATCC HTB 132) were seeded at 1500 cells/well in 40 μl of DMEM containing 10% FBS and 1% g...More data for this Ligand-Target Pair
In DepthDetails
US Patent