BDBM24518 (2E,5E)-5-[(3-nitrophenyl)methylidene]-2-(1,3-thiazol-2-ylimino)-1,3-thiazolidin-4-one::Thiazole analogue, 5

SMILES [O-][N+](=O)c1cccc(\C=C2\S\C(NC2=O)=N\c2nccs2)c1

InChI Key InChIKey=ROICXAVNWHDJPT-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 24518   

TargetProstaglandin G/H synthase 1(Sheep)
Alexander Technological Education Institute of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM24518((2E,5E)-5-[(3-nitrophenyl)methylidene]-2-(1,3-thia...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of ovine COX1 assessed as PGF2alpha production by enzyme immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetSeed linoleate 13S-lipoxygenase-1(Soybean)
Alexander Technological Education Institute of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM24518((2E,5E)-5-[(3-nitrophenyl)methylidene]-2-(1,3-thia...)
Affinity DataIC50: 8.91E+4nMAssay Description:Inhibition of soybean LOX type 1 pre-incubated for 4 mins at 7x10'-7 w/v concentration assessed as inhibition of sodium linoleate to 13-hydroperoxyli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Aristotle University

LigandPNGBDBM24518((2E,5E)-5-[(3-nitrophenyl)methylidene]-2-(1,3-thia...)
Affinity DataKi:  5.48E+5nM ΔG°:  -4.45kcal/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2008
Entry Details Article
PubMed