BDBM244422 US10226449, cpd 31::US20250017938, Compound 002-31::US9428502, 31

SMILES Cc1nc(Cl)c([nH]1)-c1cc(C(=O)N2CC(C2)c2ccc(cc2)C#N)c(C)cc1C

InChI Key InChIKey=UROMHARKWFLKDW-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 244422   

TargetFatty acid synthase(Human)
3-V Biosciences

US Patent
LigandPNGBDBM244422(US9428502, 31 | US10226449, cpd 31 | US20250017938...)
Affinity DataIC50: 11nMT: 2°CAssay Description:The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FAS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
3-V Biosciences

US Patent
LigandPNGBDBM244422(US9428502, 31 | US10226449, cpd 31 | US20250017938...)
Affinity DataIC50: 11nMAssay Description:FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetGenome polyprotein(HCV)
3-V Biosciences

US Patent
LigandPNGBDBM244422(US9428502, 31 | US10226449, cpd 31 | US20250017938...)
Affinity DataEC50:  3nMAssay Description:The antiviral activities of the compounds were assessed using the HCV1b replicon system. The replicon was constructed using the ET (luc-ubi-neo/ET) c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
3-V Biosciences

US Patent
LigandPNGBDBM244422(US9428502, 31 | US10226449, cpd 31 | US20250017938...)
Affinity DataIC50: 11nMAssay Description:Determination of FASN biochemical activity: The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent