BDBM244404 US10226449, cpd 13::US9428502, 13

SMILES Cc1nc(Cl)c([nH]1)-c1cc(ccc1C)C(=O)N1CCC(F)(CC1)c1ccc(cc1)C#N

InChI Key InChIKey=DWMPBZMKAVXYPI-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 244404   

TargetFatty acid synthase(Human)
3-V Biosciences

US Patent
LigandPNGBDBM244404(US9428502, 13 | US10226449, cpd 13)
Affinity DataIC50: 6nMT: 2°CAssay Description:The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FAS...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFatty acid synthase(Human)
3-V Biosciences

US Patent
LigandPNGBDBM244404(US9428502, 13 | US10226449, cpd 13)
Affinity DataIC50: 6nMAssay Description:FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGenome polyprotein(HCV)
3-V Biosciences

US Patent
LigandPNGBDBM244404(US9428502, 13 | US10226449, cpd 13)
Affinity DataEC50:  5nMAssay Description:The antiviral activities of the compounds were assessed using the HCV1b replicon system. The replicon was constructed using the ET (luc-ubi-neo/ET) c...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFatty acid synthase(Human)
3-V Biosciences

US Patent
LigandPNGBDBM244404(US9428502, 13 | US10226449, cpd 13)
In DepthDetails