BDBM244231 US9428501, 49

SMILES COc1ccc(CN2CCC(CC2)c2ccn3nc(cc3c2)C(=O)N2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)cn1

InChI Key InChIKey=RDVWCZZSJCEHTP-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 244231   

LigandPNGBDBM244231(US9428501, 49)
Affinity DataIC50: 18nMpH: 7.5Assay Description:Human PIK3CA mutation-positive breast cancer cell line MDA-MB-453 cells were subcutaneously implanted into nude mice, MDA-MB-453 tumor was excised, a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target5'-AMP-activated protein kinase catalytic subunit alpha-2(Human)
Astellas Pharma

US Patent
LigandPNGBDBM244231(US9428501, 49)
Affinity DataEC50:  6.5nMT: 2°CAssay Description:In order to make MDA-MB-453 cell become 15000 cells per well, each 36 μl was seeded in Leibovitz's L-15 medium including 10% fetal bovine serum (m...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM244231(US9428501, 49)
Affinity DataIC50: 2.80nMAssay Description:In order to make human PIK3 CA mutation-positive breast cancer cell line MDA-MB-453 cells become 500 cells per well in a 384 well non-adhesive plate ...More data for this Ligand-Target Pair
In DepthDetails
US Patent