BDBM243403 5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidine-2,4-diamine::US10053458, 35::US11180482, Example II-1

SMILES COc1cc2CCN(C)Cc2cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1

InChI Key InChIKey=FKFTVEPJIOFORF-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 243403   

TargetALK tyrosine kinase receptor(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM243403(5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(6-me...)
Affinity DataIC50: 10nMT: 2°CAssay Description:A proliferation inhibitory activity against the ALK of the compound represented by Chemical Formula 1 according to the present invention at an enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2018
Entry Details
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TargetALK tyrosine kinase receptor [L1196M](Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM243403(5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(6-me...)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2018
Entry Details
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TargetALK tyrosine kinase receptor(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM243403(5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(6-me...)
Affinity DataIC50: 3nMAssay Description:Inhibition of ALK (unknown origin) using peptide substrate incubated for 30 mins in presence of ATP by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM243403(5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(6-me...)
Affinity DataIC50: 30nMAssay Description:Inhibition of crizotinib-resistant ALK L1196M mutant (unknown origin) using peptide substrate incubated for 30 mins in presence of ATP by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM243403(5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(6-me...)
Affinity DataIC50: 5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
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