BDBM243373 5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(7-methoxy-2-hydroxyethyl-1,2,3,4-tetrahydroisoquinolin-6-yl)pyrimidine-2,4-diamine::US10053458, 5

SMILES COc1cc2CN(CCO)CCc2cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1

InChI Key InChIKey=KLUMLMPIENTQJN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 243373   

TargetALK tyrosine kinase receptor(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM243373(5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(7-me...)
Affinity DataIC50: 1nMT: 2°CAssay Description:A proliferation inhibitory activity against the ALK of the compound represented by Chemical Formula 1 according to the present invention at an enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2018
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor [L1196M](Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM243373(5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(7-me...)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2018
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM243373(5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(7-me...)
Affinity DataIC50: 1nMAssay Description:Inhibition of ALK (unknown origin) using peptide substrate incubated for 30 mins in presence of ATP by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM243373(5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(7-me...)
Affinity DataIC50: 10nMAssay Description:Inhibition of crizotinib-resistant ALK L1196M mutant (unknown origin) using peptide substrate incubated for 30 mins in presence of ATP by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed