BDBM24220 1-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl}piperidin-4-yl)pyrrolidin-2-one::Benzthiazole compound, 11j

SMILES O=C1CCCN1C1CCN(CCOc2ccc(Oc3nc4ccccc4s3)cc2)CC1

InChI Key InChIKey=OAUXHFPOFOZZLZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 24220   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM24220(1-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl...)
Affinity DataIC50: 2.70E+3nMT: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM24220(1-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl...)
Affinity DataIC50: 16nMpH: 7.4 T: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM24220(1-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl...)
Affinity DataIC50: 365nMAssay Description:Inhibition of LTA4H in human whole blood assessed as decrease in LTB4 productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM24220(1-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl...)
Affinity DataIC50: 9.70nMAssay Description:Inhibition of recombinant human LTA4H expressed in Sf9 cells using LTA4 as substrate incubated for 10 mins prior to substrate addition measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed