BDBM241949 US9428466, Merbarone

SMILES O=C(Nc1ccccc1)C1C(=O)NC(=S)NC1=O

InChI Key InChIKey=JARCFMKMOFFIGZ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 241949   

TargetSolute carrier family 22 member 12(Human)
TBA

US Patent
LigandPNGBDBM241949(US9428466, Merbarone)
Affinity DataIC50: 5.40E+3nMAssay Description:URAT1 (SLC22A12) activity was evaluated in a cellular uptake assay using a 96-well plate with stably transfected URAT-1/CHO cells. 3H-orotate was use...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2017
Entry Details
Go to US Patent

TargetXanthine dehydrogenase/oxidase(Human)
TBA

US Patent
LigandPNGBDBM241949(US9428466, Merbarone)
Affinity DataIC50: 2.74E+5nMAssay Description:Xanthine oxidase inhibition was determined using a standard fluorescence-based assay for xanthine oxidase activity (McHale A, Grimes H, Coughlan M P:...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2017
Entry Details
Go to US Patent

TargetDNA topoisomerase 2-alpha(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM241949(US9428466, Merbarone)
Affinity DataIC50: 1.20E+5nMAssay Description:Inhibition of human topoisomerase 2alpha expressed in baculovirus-infected insect cells assessed as reduction in pBR322 supercoiled DNA relaxation af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2019
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM241949(US9428466, Merbarone)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of human topoisomerase 2alpha-mediated relaxation of supercoiled pBR322 after 1 hr by ethidium bromide stainingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM241949(US9428466, Merbarone)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human topo2alpha by plasmid relaxation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM241949(US9428466, Merbarone)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of human topo2alpha incubated for 30 mins by SYBR safe DNA stain based decatenation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
TBA

US Patent
LigandPNGBDBM241949(US9428466, Merbarone)
Affinity DataIC50: 2.74E+5nMAssay Description:Inhibition of human xanthine oxidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
TBA

US Patent
LigandPNGBDBM241949(US9428466, Merbarone)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of human URAT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed