BDBM240604 US9409882, 9

SMILES Fc1ccc(cc1)-c1cccc(S[C@@H]2C[C@H](N(C2)C(=O)C2(CC2)c2ncc(Cl)cc2F)C(=O)NC2(CC2)C#N)c1

InChI Key InChIKey=KNYVBCIARVQYNI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 240604   

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM240604(US9409882, 9)
Affinity DataIC50: 11.8nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
Go to US Patent

TargetProcathepsin L(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM240604(US9409882, 9)
Affinity DataIC50: 417nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
Go to US Patent