BDBM240596 US9409882, 1

SMILES COc1ccc(c(Cl)c1)S(=O)(=O)[C@@H]1C[C@H](N(C1)C(=O)C1(CC1)c1ccc(Cl)cn1)C(=O)NC1(CC1)C#N

InChI Key InChIKey=BABQKRHMVVUNBI-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 240596   

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM240596(US9409882, 1)
Affinity DataIC50: 0.606nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
Go to US Patent

TargetProcathepsin L(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM240596(US9409882, 1)
Affinity DataIC50: 410nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
Go to US Patent

TargetProcathepsin L(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM240596(US9409882, 1)
Affinity DataIC50: 410nMAssay Description:Inhibition of human Cathepsin LMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM240596(US9409882, 1)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of Cathepsin S (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCathepsin K(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM240596(US9409882, 1)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of Cathepsin K (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed