BDBM239103 US10195181, Example 4::US9403810, 4

SMILES Cc1c(noc1C1=CCC2(CCOC2)CC1)C(=O)Nc1c(C)n(C)n(C2CCCCC2)c1=O

InChI Key InChIKey=VTZQGRKKFFSIKM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 239103   

TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandPNGBDBM239103(US9403810, 4 | US10195181, Example 4)
Affinity DataIC50: 100nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details
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TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM239103(US9403810, 4 | US10195181, Example 4)
Affinity DataIC50: 100nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent