BDBM238272 US9409887, I-3

SMILES COc1cc(NC2CN(C2)C(=O)OC(C)(C)C)ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F

InChI Key InChIKey=UDVRGRBOAMOTGS-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 238272   

TargetEpidermal growth factor receptor [668-1210](Human)
Celgene Avilomics Research

US Patent
LigandPNGBDBM238272(US9409887, I-3)
Affinity DataIC50: 200nMpH: 7.5Assay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Human)
Celgene Avilomics Research

US Patent
LigandPNGBDBM238272(US9409887, I-3)
Affinity DataIC50: 5nMpH: 7.5Assay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor [668-1210](Human)
Celgene Avilomics Research

US Patent
LigandPNGBDBM238272(US9409887, I-3)
Affinity DataEC50: >1.00E+3nMAssay Description:A431 human epidermoid carcinoma, H1975 human NSCLC and HCC827 human NSCLC adenocarcinoma cells were obtained from the American Type Culture Center (M...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Human)
Celgene Avilomics Research

US Patent
LigandPNGBDBM238272(US9409887, I-3)
Affinity DataEC50:  300nMAssay Description:A431 human epidermoid carcinoma, H1975 human NSCLC and HCC827 human NSCLC adenocarcinoma cells were obtained from the American Type Culture Center (M...More data for this Ligand-Target Pair
In DepthDetails
US Patent