BDBM238258 US10882855, Example 69::US9394250, 69::US9585881, Example 69

SMILES COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)[C@@H]1C[C@@H](CN1C(=O)C1CCN(CC1)C(N)=N)C1CCN(CC1)S(C)(=O)=O

InChI Key InChIKey=JTPXUJBMJBRDKQ-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 238258   

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM238258(US9394250, 69 | US9585881, Example 69 | US10882855...)
Affinity DataIC50: 7.40nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProthrombin(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM238258(US9394250, 69 | US9585881, Example 69 | US10882855...)
Affinity DataIC50: 1.00E+5nMAssay Description:Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCoagulation factor X(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM238258(US9394250, 69 | US9585881, Example 69 | US10882855...)
Affinity DataIC50: 1.00E+5nMAssay Description:Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM238258(US9394250, 69 | US9585881, Example 69 | US10882855...)
Affinity DataIC50: 7.40nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProthrombin(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM238258(US9394250, 69 | US9585881, Example 69 | US10882855...)
Affinity DataIC50: 1.00E+5nMAssay Description:Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCoagulation factor X(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM238258(US9394250, 69 | US9585881, Example 69 | US10882855...)
Affinity DataIC50: 1.00E+5nMAssay Description:Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM238258(US9394250, 69 | US9585881, Example 69 | US10882855...)
Affinity DataIC50: 7.40nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProthrombin(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM238258(US9394250, 69 | US9585881, Example 69 | US10882855...)
Affinity DataIC50: 1.00E+5nMAssay Description:Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCoagulation factor X(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM238258(US9394250, 69 | US9585881, Example 69 | US10882855...)
Affinity DataIC50: 1.00E+5nMAssay Description:Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...More data for this Ligand-Target Pair
In DepthDetails
US Patent