BDBM238254 US10882855, Example 39::US9394250, 39::US9585881, Example 39

SMILES Clc1ccc(c(\C=C\C(=O)N2C[C@H](C[C@H]2C(=O)Nc2ccccc2)N2CCN(CC2)S(=O)(=O)c2ccccc2)c1)-n1cnnn1

InChI Key InChIKey=MOLPVSKHMAUZQO-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 238254   

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM238254(US9394250, 39 | US9585881, Example 39 | US10882855...)
Affinity DataIC50: 78nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProthrombin(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM238254(US9394250, 39 | US9585881, Example 39 | US10882855...)
Affinity DataIC50: 1.00E+5nMAssay Description:Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCoagulation factor X(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM238254(US9394250, 39 | US9585881, Example 39 | US10882855...)
Affinity DataIC50: 1.00E+5nMAssay Description:Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM238254(US9394250, 39 | US9585881, Example 39 | US10882855...)
Affinity DataIC50: 78nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProthrombin(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM238254(US9394250, 39 | US9585881, Example 39 | US10882855...)
Affinity DataIC50: 1.00E+5nMAssay Description:Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCoagulation factor X(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM238254(US9394250, 39 | US9585881, Example 39 | US10882855...)
Affinity DataIC50: 1.00E+5nMAssay Description:Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM238254(US9394250, 39 | US9585881, Example 39 | US10882855...)
Affinity DataIC50: 78nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProthrombin(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM238254(US9394250, 39 | US9585881, Example 39 | US10882855...)
Affinity DataIC50: 1.00E+5nMAssay Description:Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCoagulation factor X(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM238254(US9394250, 39 | US9585881, Example 39 | US10882855...)
Affinity DataIC50: 1.00E+5nMAssay Description:Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...More data for this Ligand-Target Pair
In DepthDetails
US Patent