BDBM238152 US10017502, Example 2::US9394291, 2::US9394291, 2a

SMILES CNC(=O)CC1COc2ccccc2N1C(=O)c1ccc2OCC(=O)Nc2c1

InChI Key InChIKey=GNKWYKHEEWCEKY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 238152   

TargetMineralocorticoid receptor [729-984](Human)
Astrazeneca

US Patent
LigandPNGBDBM238152(US9394291, 2a | US9394291, 2 | US10017502, Example...)
Affinity DataIC50: 230nMpH: 7.5Assay Description:Test A1: Briefly, in Test A1 the assay was run in 384 well format in 10 mM Tris-HCl, pH 7.5, 0.5 mM EDTA 20 mM NaMoO4, 0.1 mM DTT and 10% glycerol at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
Go to US Patent

TargetMineralocorticoid receptor [729-984](Human)
Astrazeneca

US Patent
LigandPNGBDBM238152(US9394291, 2a | US9394291, 2 | US10017502, Example...)
Affinity DataIC50: 1.80E+3nMpH: 7.5Assay Description:Test A2: Briefly, in Test A1 the assay was run in 384 well format in 10 mM Tris-HCl, pH 7.5, 0.5 mM EDTA 20 mM NaMoO4, 0.1 mM DTT and 10% glycerol at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
Go to US Patent

TargetMineralocorticoid receptor [729-984](Human)
Astrazeneca

US Patent
LigandPNGBDBM238152(US9394291, 2a | US9394291, 2 | US10017502, Example...)
Affinity DataIC50: 1.80E+3nMAssay Description:Test A1 and A2: In order to identify binding to the human MR LBD a scintillation proximity assay (SPA) was adapted to the 384-well format. The MR-LBD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
Go to US Patent