BDBM235832 US9364482, 6

SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2OCN(Cc3ccc(F)cc3)C(=O)c2n1)-c1ccc(F)cc1

InChI Key InChIKey=VTLCWLDIFFWTOF-UHFFFAOYSA-N

Data  2 IC50  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 235832   

TargetGenome polyprotein [1027-1711](HCV)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM235832(US9364482, 6)
Affinity DataIC50: 2.78nMAssay Description:Stable neomycin phosphotransferase encoding replicons-harboring cell lines were used, so all cell lines were maintained under G418 selection prior to...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGenome polyprotein [1027-1711](HCV)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM235832(US9364482, 6)
Affinity DataIC50: 1.93nMAssay Description:Stable neomycin phosphotransferase encoding replicons-harboring cell lines were used, so all cell lines were maintained under G418 selection prior to...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Merck

Curated by ChEMBL
LigandPNGBDBM235832(US9364482, 6)
Affinity DataEC50:  1.60nMAssay Description:Non-nucleoside inhibition of NS5B polymerase in HCV genotype 1a by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Merck

Curated by ChEMBL
LigandPNGBDBM235832(US9364482, 6)
Affinity DataEC50:  1.30nMAssay Description:Non-nucleoside inhibition of NS5B polymerase in HCV genotype 1b by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Merck

Curated by ChEMBL
LigandPNGBDBM235832(US9364482, 6)
Affinity DataEC50:  4.60nMAssay Description:Non-nucleoside inhibition of NS5B polymerase in HCV genotype 2a by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Merck

Curated by ChEMBL
LigandPNGBDBM235832(US9364482, 6)
Affinity DataEC50:  19nMAssay Description:Non-nucleoside inhibition of NS5B polymerase in HCV genotype 2b by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Merck

Curated by ChEMBL
LigandPNGBDBM235832(US9364482, 6)
Affinity DataEC50:  1.80nMAssay Description:Non-nucleoside inhibition of NS5B polymerase in HCV genotype 3a by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Merck

Curated by ChEMBL
LigandPNGBDBM235832(US9364482, 6)
Affinity DataEC50:  0.300nMAssay Description:Non-nucleoside inhibition of NS5B polymerase in HCV genotype 4a by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Merck

Curated by ChEMBL
LigandPNGBDBM235832(US9364482, 6)
Affinity DataEC50:  3.5nMAssay Description:Non-nucleoside inhibition of NS5B polymerase C316Y mutant in HCV genotype 1a by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Merck

Curated by ChEMBL
LigandPNGBDBM235832(US9364482, 6)
Affinity DataEC50:  0.700nMAssay Description:Non-nucleoside inhibition of NS5B polymerase S365A mutant in HCV genotype 1a by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed