BDBM235742 US9359371, 11
SMILES COc1ccc(CNc2nc(ncc2C(=O)N[C@H]2CC[C@H](O)CC2)N2CC3CC3C2)cc1Cl
InChI Key InChIKey=NKAVILAJSNUOES-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 235742
Affinity DataIC50: 4.02nMpH: 7.5Assay Description:To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...More data for this Ligand-Target Pair
Affinity DataIC50: 1.31nMpH: 7.5Assay Description:The test compound or solvent was incubated at 25° C. for 15 min with enzyme solution (35 μg/mL) in Tris-HCl buffer of pH 7.5. 1 μM cGMP and...More data for this Ligand-Target Pair
Affinity DataIC50: 0.410nMpH: 7.5Assay Description:The test compound or solvent was incubated at 25° C. for 15 min with enzyme solution (35 μg/mL) in Tris-HCl buffer of pH 7.5. 1 μM cGMP and...More data for this Ligand-Target Pair
Affinity DataIC50: 61nMpH: 7.5Assay Description:Method: The test compound or solvent was incubated at 25° C. for 15 min with enzyme solution (0.2 μg/mL) in Tris-HCl buffer of pH 7.5. 100 μ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMpH: 7.5Assay Description:To a 96-well plate, 20 μL of 10 μM FL-cGMP as the substrate was added; then 1 μL solution of the compound in DMSO or DMSO solution wit...More data for this Ligand-Target Pair