BDBM235733 US9359371, 1

SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ncccn2)N2CC3CC3C2)cc1Cl

InChI Key InChIKey=MZTKPBZVHILACH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 235733   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase [537-875](Human)
Xuanzhu Pharma

US Patent
LigandPNGBDBM235733(US9359371, 1)
Affinity DataIC50: 6.04nMpH: 7.5Assay Description:To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
Go to US Patent

TargetcGMP-specific 3',5'-cyclic phosphodiesterase [537-875](Human)
Xuanzhu Pharma

US Patent
LigandPNGBDBM235733(US9359371, 1)
Affinity DataIC50: 6.04nMpH: 7.5Assay Description:The test compound or solvent was incubated at 25° C. for 15 min with enzyme solution (35 μg/mL) in Tris-HCl buffer of pH 7.5. 1 μM cGMP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
Go to US Patent

TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Xuanzhu Pharma

US Patent
LigandPNGBDBM235733(US9359371, 1)
Affinity DataIC50: 1.00E+4nMpH: 7.5Assay Description:To a 96-well plate, 20 μL of 10 μM FL-cGMP as the substrate was added; then 1 μL solution of the compound in DMSO or DMSO solution wit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
Go to US Patent