BDBM23410 2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4H-chromen-4-one::CHEMBL312163::Rhamnetin

SMILES COc1cc(c2c(c1)OC(=C(C2=O)O)c3ccc(c(c3)O)O)O

InChI Key InChIKey=JGUZGNYPMHHYRK-UHFFFAOYSA-N

Data  8 IC50  1 Other

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 23410   

TargetAlpha-amylase 1A(Human)
Nestle Research Center

LigandPNGBDBM23410(CHEMBL312163 | 2-(3,4-dihydroxyphenyl)-3,5-dihydro...)
Affinity DatapH: 6.0 T: 2°CAssay Description:The assay was carried out at room temperature for 10 min with salivary alpha-amylase, starch, and test compounds. The reducing sugar was determined b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2008
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM23410(CHEMBL312163 | 2-(3,4-dihydroxyphenyl)-3,5-dihydro...)
Affinity DataIC50: 6.16E+4nMAssay Description:IC50 was measured as concentration required to inhibit 50% of HIV-integrase cleavageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
King'S College London

Curated by ChEMBL
LigandPNGBDBM23410(CHEMBL312163 | 2-(3,4-dihydroxyphenyl)-3,5-dihydro...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of human recombinant aldose reductase using D-glyceraldehyde as substrate preincubated for 10 mins before substrate addition measured for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM23410(CHEMBL312163 | 2-(3,4-dihydroxyphenyl)-3,5-dihydro...)
Affinity DataIC50: 2.87E+4nMAssay Description:IC50 was measured as concentration required to inhibit 50% of HIV-integrase integrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetPancreatic alpha-amylase(Pig)
University of Basilicata

Curated by ChEMBL
LigandPNGBDBM23410(CHEMBL312163 | 2-(3,4-dihydroxyphenyl)-3,5-dihydro...)
Affinity DataIC50: 7.39E+4nMAssay Description:Inhibition of hog pancreas alpha-amylase using starch as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2018
Entry Details Article
PubMed
TargetELAV-like protein 3(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM23410(CHEMBL312163 | 2-(3,4-dihydroxyphenyl)-3,5-dihydro...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of ELAV3 (unknown origin)-artificial ARE complex formation after 30 mins in the presence of biotin-labeled RNA probe by chemiluminescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2019
Entry Details Article
PubMed
TargetInositol hexakisphosphate kinase 2(Human)
National Institute of Environmental Health Sciences

Curated by ChEMBL
LigandPNGBDBM23410(CHEMBL312163 | 2-(3,4-dihydroxyphenyl)-3,5-dihydro...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human IP6K2 using insP6 as substrate preincubated for 15 mins followed by substrate and measured after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetInositol polyphosphate multikinase(Human)
National Institute of Environmental Health Sciences

Curated by ChEMBL
LigandPNGBDBM23410(CHEMBL312163 | 2-(3,4-dihydroxyphenyl)-3,5-dihydro...)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human IPMK using insP3 as substrate preincubated for 15 mins followed by substrate and measured after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAmyloid-beta precursor protein(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM23410(CHEMBL312163 | 2-(3,4-dihydroxyphenyl)-3,5-dihydro...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of amyloid beta (1 to 42) (unknown origin) fibril formation incubated for 1 hr by thioflavin-T fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed