BDBM22987 (5Z,8Z,11Z,14Z)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]icosa-5,8,11,14-tetraenamide::Arachidonylserotonin::CHEMBL191534::N-arachidonoylserotonin (AA-5-HT)

SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCCc1c[nH]c2ccc(O)cc12

InChI Key InChIKey=QJDNHGXNNRLIGA-UHFFFAOYSA-N

Data  8 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 22987   

TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Sapienza University of Rome

LigandPNGBDBM22987(CHEMBL191534 | Arachidonylserotonin | (5Z,8Z,11Z,1...)
Affinity DataIC50: 8.00E+3nMpH: 9.0 T: 2°CAssay Description:The effect of the test compounds on the enzymatic hydrolysis of [14C]anandamide was evaluated by using membranes prepared from rat brain. [14C]Ethano...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2008
Entry Details Article
PubMed
LigandPNGBDBM22987(CHEMBL191534 | Arachidonylserotonin | (5Z,8Z,11Z,1...)
Affinity DataIC50: 270nMAssay Description:The effect of the test compounds on the enzymatic hydrolysis of [14C]anandamide was evaluated by using membranes prepared from rat brain. [14C]Ethano...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2008
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM22987(CHEMBL191534 | Arachidonylserotonin | (5Z,8Z,11Z,1...)
Affinity DataEC50: >2.50E+4nMAssay Description:Antagonist activity at human TRPA1 expressed in HEK293 cells assessed as decrease in intracellular calcium levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Roseman University of Health Sciences

Curated by ChEMBL
LigandPNGBDBM22987(CHEMBL191534 | Arachidonylserotonin | (5Z,8Z,11Z,1...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant COX2 assessed as inhibition of ADHP to fluorescent resorufin conversion by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2016
Entry Details Article
PubMed
LigandPNGBDBM22987(CHEMBL191534 | Arachidonylserotonin | (5Z,8Z,11Z,1...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human TRPV1 overexpressed in BEAS-2B cells assessed as calcium flux after 30 mins by Fluo-4 AM fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2016
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Roseman University of Health Sciences

Curated by ChEMBL
LigandPNGBDBM22987(CHEMBL191534 | Arachidonylserotonin | (5Z,8Z,11Z,1...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of human recombinant FAAH using AMC arachidonoyl amide as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2016
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Roseman University of Health Sciences

Curated by ChEMBL
LigandPNGBDBM22987(CHEMBL191534 | Arachidonylserotonin | (5Z,8Z,11Z,1...)
Affinity DataIC50: 1.20E+4nMAssay Description:Irreversible inhibition of fatty acid amide hydrolase; range=. 5-6 nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Sapienza University of Rome

LigandPNGBDBM22987(CHEMBL191534 | Arachidonylserotonin | (5Z,8Z,11Z,1...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of rat brain FAAH using [3H]AEA as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2020
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Roseman University of Health Sciences

Curated by ChEMBL
LigandPNGBDBM22987(CHEMBL191534 | Arachidonylserotonin | (5Z,8Z,11Z,1...)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of FAAH (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed