BDBM22890 2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid::CHEMBL1000::Cetirizine::Levocetirizine

SMILES OC(=O)COCCN1CCN(CC1)C(c1ccccc1)c1ccc(Cl)cc1

InChI Key InChIKey=ZKLPARSLTMPFCP-UHFFFAOYSA-N

Data  9 KI  7 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 22890   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM22890(CHEMBL1000 | 2-(2-{4-[(4-chlorophenyl)(phenyl)meth...)
Affinity DataIC50: 1.08E+5nMAssay Description:Inhibitory concentration against IKr potassium channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Zhejiang Gongshang University

Curated by ChEMBL
LigandPNGBDBM22890(CHEMBL1000 | 2-(2-{4-[(4-chlorophenyl)(phenyl)meth...)
Affinity DataKd:  9.00E+4nMAssay Description:Binding affinity to human recombinant Tie2 by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM22890(CHEMBL1000 | 2-(2-{4-[(4-chlorophenyl)(phenyl)meth...)
Affinity DataIC50: 3.02E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM22890(CHEMBL1000 | 2-(2-{4-[(4-chlorophenyl)(phenyl)meth...)
Affinity DataIC50: 3.02E+4nMAssay Description:Inhibitory concentration against potassium channel HERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetMultidrug and toxin extrusion protein 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM22890(CHEMBL1000 | 2-(2-{4-[(4-chlorophenyl)(phenyl)meth...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM22890(CHEMBL1000 | 2-(2-{4-[(4-chlorophenyl)(phenyl)meth...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG potassium channel in HEK293 cells by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM22890(CHEMBL1000 | 2-(2-{4-[(4-chlorophenyl)(phenyl)meth...)
Affinity DataIC50: 3.16E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM22890(CHEMBL1000 | 2-(2-{4-[(4-chlorophenyl)(phenyl)meth...)
Affinity DataIC50: 3.02E+4nMAssay Description:Inhibition of human Potassium channel HERG expressed in mammalian cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Ucb Pharma

Curated by PDSP Ki Database
LigandPNGBDBM22890(CHEMBL1000 | 2-(2-{4-[(4-chlorophenyl)(phenyl)meth...)
Affinity DataKi:  3.16nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Ucb Pharma

Curated by PDSP Ki Database
LigandPNGBDBM22890(CHEMBL1000 | 2-(2-{4-[(4-chlorophenyl)(phenyl)meth...)
Affinity DataKi:  5.89nMAssay Description:Binding affinity for human Histamine H1 receptor in CHO K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H1 receptor(Guinea pig)
UniversitÉ

Curated by PDSP Ki Database
LigandPNGBDBM22890(CHEMBL1000 | 2-(2-{4-[(4-chlorophenyl)(phenyl)meth...)
Affinity DataKi:  12.6nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2011
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Ucb Pharma

Curated by PDSP Ki Database
LigandPNGBDBM22890(CHEMBL1000 | 2-(2-{4-[(4-chlorophenyl)(phenyl)meth...)
Affinity DataKi:  14nMAssay Description:Inhibition constant against histamine H1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Ucb Pharma

Curated by PDSP Ki Database
LigandPNGBDBM22890(CHEMBL1000 | 2-(2-{4-[(4-chlorophenyl)(phenyl)meth...)
Affinity DataKi:  14nMAssay Description:Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Ucb Pharma

Curated by PDSP Ki Database
LigandPNGBDBM22890(CHEMBL1000 | 2-(2-{4-[(4-chlorophenyl)(phenyl)meth...)
Affinity DataKi:  14nMAssay Description:In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Ucb Pharma

Curated by PDSP Ki Database
LigandPNGBDBM22890(CHEMBL1000 | 2-(2-{4-[(4-chlorophenyl)(phenyl)meth...)
Affinity DataKi:  50nMAssay Description:Binding affinity for H1 histamine receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Ucb Pharma

Curated by PDSP Ki Database
LigandPNGBDBM22890(CHEMBL1000 | 2-(2-{4-[(4-chlorophenyl)(phenyl)meth...)
Affinity DataKi:  50.1nMAssay Description:Displacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Vrije Universiteit Amsterdam

LigandPNGBDBM22890(CHEMBL1000 | 2-(2-{4-[(4-chlorophenyl)(phenyl)meth...)
Affinity DataKi: >1.00E+4nM ΔG°: >-7.09kcal/molepH: 7.4 T: 2°CAssay Description:Ligand displacement assays were performed on The SK-N-MC/hH4R cell homogenates. Retained radioactivity was determined by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2008
Entry Details Article
PubMed