BDBM228645 US10111875, Compound 47::US10369153, Compound 47::US9346810, 47

SMILES CNS(=O)(=O)N(C)[C@@H]1CCN(C1)c1ncnc2[nH]ccc12

InChI Key InChIKey=JNTHYJIRPFWUKF-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 228645   

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Hutchison Medipharma

US Patent
LigandPNGBDBM228645(US9346810, 47 | US10111875, Compound 47 | US103691...)
Affinity DataIC50: 119nMT: 2°CAssay Description:JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2017
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Hutchison Medipharma

US Patent
LigandPNGBDBM228645(US9346810, 47 | US10111875, Compound 47 | US103691...)
Affinity DataIC50: 98nMT: 2°CAssay Description:JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2017
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3 [781-1124](Human)
Hutchison Medipharma

US Patent
LigandPNGBDBM228645(US9346810, 47 | US10111875, Compound 47 | US103691...)
Affinity DataIC50: 157nMT: 2°CAssay Description:JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2017
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Hutchison Medipharma

US Patent
LigandPNGBDBM228645(US9346810, 47 | US10111875, Compound 47 | US103691...)
Affinity DataIC50: 0.0550nMT: 2°CAssay Description:JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2017
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Hutchinson Medipharma

US Patent
LigandPNGBDBM228645(US9346810, 47 | US10111875, Compound 47 | US103691...)
Affinity DataIC50: 119nMT: 2°CAssay Description:JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Hutchinson Medipharma

US Patent
LigandPNGBDBM228645(US9346810, 47 | US10111875, Compound 47 | US103691...)
Affinity DataIC50: 98nMT: 2°CAssay Description:JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Hutchinson Medipharma

US Patent
LigandPNGBDBM228645(US9346810, 47 | US10111875, Compound 47 | US103691...)
Affinity DataIC50: 157nMT: 2°CAssay Description:JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Hutchinson Medipharma

US Patent
LigandPNGBDBM228645(US9346810, 47 | US10111875, Compound 47 | US103691...)
Affinity DataIC50: 100nMAssay Description:JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Hutchinson Medipharma

US Patent
LigandPNGBDBM228645(US9346810, 47 | US10111875, Compound 47 | US103691...)
Affinity DataIC50: 119nMAssay Description:JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Hutchinson Medipharma

US Patent
LigandPNGBDBM228645(US9346810, 47 | US10111875, Compound 47 | US103691...)
Affinity DataIC50: 98nMAssay Description:JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Hutchinson Medipharma

US Patent
LigandPNGBDBM228645(US9346810, 47 | US10111875, Compound 47 | US103691...)
Affinity DataIC50: 157nMAssay Description:JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
Go to US Patent