BDBM22851 1,2-Dione-Based Compound, 8::1,2-dihydronaphthalene-1,2-dione::1,2-naphthoquinone::CHEMBL52347::cid_10667

SMILES O=C1C=Cc2ccccc2C1=O

InChI Key InChIKey=KETQAJRQOHHATG-UHFFFAOYSA-N

Data  4 KI  23 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 22851   

TargetDual specificity protein phosphatase 6(Rat)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM22851(1,2-dihydronaphthalene-1,2-dione | 1,2-naphthoquin...)
Affinity DataIC50: 5.00E+4nMAssay Description:The MKP-3 dose response assay Active/Probe Assessment Assay - Reproducibility testing has been developed to test the reproducibility of MKP-3 inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetTyrosine-protein phosphatase non-receptor type 22(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM22851(1,2-dihydronaphthalene-1,2-dione | 1,2-naphthoquin...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of LYP (unknown origin) using DiFMUP substrate incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2016
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM22851(1,2-dihydronaphthalene-1,2-dione | 1,2-naphthoquin...)
Affinity DataIC50: 1.64E+3nMAssay Description:In vitro inhibitory activity against recombinant human protein-tyrosine phosphatase 1B (PTP1B) using fluorescein diphosphate (FDP) as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPapain(Papaya)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM22851(1,2-dihydronaphthalene-1,2-dione | 1,2-naphthoquin...)
Affinity DataIC50: 1.20E+5nMAssay Description:Inhibitory activity against papain using HPLC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase C(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM22851(1,2-dihydronaphthalene-1,2-dione | 1,2-naphthoquin...)
Affinity DataIC50: 3.00E+3nMAssay Description:In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGenome polyprotein(Human rhinovirus B)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM22851(1,2-dihydronaphthalene-1,2-dione | 1,2-naphthoquin...)
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibitory activity against HRV 3Cpro using HPLC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetM-phase inducer phosphatase 2(Human)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM22851(1,2-dihydronaphthalene-1,2-dione | 1,2-naphthoquin...)
Affinity DataIC50: 1.90E+4nMAssay Description:The MKP-1 Dual Specificity Protein Tyrosine Phosphatase Probe Assessment Cdc25B Dose Response Selectivity Assay has been developed to evaluate the PT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetDual specificity protein phosphatase 1(Human)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM22851(1,2-dihydronaphthalene-1,2-dione | 1,2-naphthoquin...)
Affinity DataIC50: 5.00E+4nMAssay Description:The Cdc25B Phosphatase probe assessment MKP-1 dose response selectivity assay has been developed to test the phosphatase specificity of actives that ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetDual specificity protein phosphatase 6(Rat)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM22851(1,2-dihydronaphthalene-1,2-dione | 1,2-naphthoquin...)
Affinity DataIC50: 5.00E+4nMAssay Description:The Cdc25B Phosphatase probe assessment MKP-1 dose response selectivity assay has been developed to test the phosphatase specificity of actives that ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetM-phase inducer phosphatase 2(Human)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM22851(1,2-dihydronaphthalene-1,2-dione | 1,2-naphthoquin...)
Affinity DataIC50: 2.50E+4nMAssay Description:The Cdc25B Phosphatase probe assessment dose response assay in Glutathione (GSH) has been developed to assess actives that were identified in the Cdc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetM-phase inducer phosphatase 2(Human)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM22851(1,2-dihydronaphthalene-1,2-dione | 1,2-naphthoquin...)
Affinity DataIC50: 2.04E+4nMAssay Description:The Cdc25B Phosphatase probe assessment dose response assay in Beta-Mercaptoethanol (BME) has been developed to assess actives that were identified i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetM-phase inducer phosphatase 2(Human)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM22851(1,2-dihydronaphthalene-1,2-dione | 1,2-naphthoquin...)
Affinity DataIC50: 5.00E+4nMAssay Description:The Cdc25B Phosphatase probe assessment dose response assay in 25 mM DTT with Catalase has been developed to assess actives that were identified in t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetM-phase inducer phosphatase 2(Human)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM22851(1,2-dihydronaphthalene-1,2-dione | 1,2-naphthoquin...)
Affinity DataIC50: 2.54E+4nMAssay Description:The Cdc25B Phosphatase probe assessment dose response assay in Catalase has been developed to assess actives that were identified in the Cdc25B HTS A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetM-phase inducer phosphatase 2(Human)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM22851(1,2-dihydronaphthalene-1,2-dione | 1,2-naphthoquin...)
Affinity DataIC50: 1.31E+4nMAssay Description:The Cdc25B Phosphatase HTS dose response confirmation has been developed to confirm actives identified in the Cdc25B HTS AID 368, screened at the Uni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetIndoleamine 2,3-dioxygenase 1(Human)
Bryn Mawr College

LigandPNGBDBM22851(1,2-dihydronaphthalene-1,2-dione | 1,2-naphthoquin...)
Affinity DataIC50: 7.10E+3nMpH: 6.5 T: 2°CAssay Description:The IC50 inhibition assays were performed in a 96-well microtiter plate format using purified recombinant IDO, which was added to the substrate, L-tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2008
Entry Details Article
PubMed
TargetDual specificity protein phosphatase 6(Rat)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM22851(1,2-dihydronaphthalene-1,2-dione | 1,2-naphthoquin...)
Affinity DataIC50: 5.00E+4nMAssay Description:The MKP-3 dose response Active/Probe assessment-Catalase assay has been developed to evaluate the effects of adding 100 U/mL of Catalase on the MKP-3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetDual specificity protein phosphatase 1(Human)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM22851(1,2-dihydronaphthalene-1,2-dione | 1,2-naphthoquin...)
Affinity DataIC50: 3.64E+4nMAssay Description:The MKP-1 dose response assay Active/Probe Assessment Assay - Reproducibility testing has been developed to test the reproducibility of MKP-1 inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetM-phase inducer phosphatase 2(Human)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM22851(1,2-dihydronaphthalene-1,2-dione | 1,2-naphthoquin...)
Affinity DataIC50: 1.22E+4nMAssay Description:The Cdc25B Phosphatase probe assessment dose response reproducibility assay has been developed to re-confirm actives that were identified in the Cdc2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetM-phase inducer phosphatase 2(Human)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM22851(1,2-dihydronaphthalene-1,2-dione | 1,2-naphthoquin...)
Affinity DataIC50: 5.00E+4nMAssay Description:The Cdc25B Phosphatase probe assessment dose response assay in 25 mM DTT has been developed to assess actives that were identified in the Cdc25B HTS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetDual specificity protein phosphatase 6(Rat)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM22851(1,2-dihydronaphthalene-1,2-dione | 1,2-naphthoquin...)
Affinity DataIC50: 1.83E+3nMAssay Description:The in vitro MKP-3 Phosphatase dose response hit/probe assessment assay has been developed and run at the University of Pittsburgh Molecular Screenin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2011
Entry Details
PCBioAssay
TargetDual specificity protein phosphatase 1(Human)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM22851(1,2-dihydronaphthalene-1,2-dione | 1,2-naphthoquin...)
Affinity DataIC50: 2.25E+4nMAssay Description:The MKP-1 dose response Active/Probe assessment-Catalase assay has been developed to evaluate the effects of adding 100 U/mL of Catalase on the MKP-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetDual specificity protein phosphatase 1(Human)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM22851(1,2-dihydronaphthalene-1,2-dione | 1,2-naphthoquin...)
Affinity DataIC50: 2.25E+4nMAssay Description:The MKP-1 dose response Active/Probe assessment-DTT assay has been developed to evaluate the effects of increased DTT concentration on the MKP-1 inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetDual specificity protein phosphatase 1(Human)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM22851(1,2-dihydronaphthalene-1,2-dione | 1,2-naphthoquin...)
Affinity DataIC50: 1.84E+4nMpH: 7.0 T: 2°CAssay Description:The MKP-1 HTS confirmation dose response assay has been developed to confirm actives identified in the MH-76391 In vitro HTS assay for MKP-1 inhibito...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2009
Entry Details
PCBioAssay
TargetAcetylcholinesterase(Human)
St. Jude Research Hospital

LigandPNGBDBM22851(1,2-dihydronaphthalene-1,2-dione | 1,2-naphthoquin...)
Affinity DataKi:  320nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Estimates of the competitive inhibition constants (Ki) were ob...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2008
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
St. Jude Research Hospital

LigandPNGBDBM22851(1,2-dihydronaphthalene-1,2-dione | 1,2-naphthoquin...)
Affinity DataKi:  930nM ΔG°:  -8.22kcal/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2008
Entry Details Article
PubMed
TargetCholinesterase(Human)
St. Jude Research Hospital

LigandPNGBDBM22851(1,2-dihydronaphthalene-1,2-dione | 1,2-naphthoquin...)
Affinity DataKi:  2.29E+3nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
St. Jude Research Hospital

LigandPNGBDBM22851(1,2-dihydronaphthalene-1,2-dione | 1,2-naphthoquin...)
Affinity DataKi:  2.40E+3nM ΔG°:  -7.66kcal/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2008
Entry Details Article
PubMed