BDBM228156 (R)-5-(2-morpholino-5a,6,8,9-tetrahydro-5H- pyrimido[5',4':4,5]pyrrolo[2,1-c][1,4]oxazin-4- yl)pyrimidin-2-amine::US9556203, 41

SMILES Nc1ncc(cn1)-c1nc(nc2N3CCOC[C@H]3Cc12)N1CCOCC1

InChI Key InChIKey=KDKHUZABTIJMDY-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 228156   

TargetTarget of rapamycin complex subunit LST8(Human)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM228156((R)-5-(2-morpholino-5a,6,8,9-tetrahydro-5H- pyrimi...)
Affinity DataIC50: 574nMAssay Description:Inhibition of mTORC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetTarget of rapamycin complex 2 subunit MAPKAP1(Human)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM228156((R)-5-(2-morpholino-5a,6,8,9-tetrahydro-5H- pyrimi...)
Affinity DataIC50: 575nMAssay Description:Inhibition of mTORC2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
LigandPNGBDBM228156((R)-5-(2-morpholino-5a,6,8,9-tetrahydro-5H- pyrimi...)
Affinity DataKi:  23nM IC50: 231nMpH: 7.5Assay Description:N-terminally His-tagged PI3K alpha (Cat. No. PV4789; 0.49 mg/ml), Alexa Fluor 647 labeled kinase Tracer 314 (Cat. No. PV6087), Biotin anti-His Tag an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2018
Entry Details
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