BDBM228130 (R)-5-(4-morpholino-5a,6,8,9-tetrahydro-5H- pyrimido[5',4':4,5]pyrrolo[2,1-c][1,4]oxazin-2- yl)-4-(trifluoromethyl)pyridin-2-amine::US9556203, 6

SMILES Nc1cc(c(cn1)-c1nc2N3CCOC[C@H]3Cc2c(n1)N1CCOCC1)C(F)(F)F

InChI Key InChIKey=VEUJAZRDHNBJQE-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 228130   

LigandPNGBDBM228130((R)-5-(4-morpholino-5a,6,8,9-tetrahydro-5H- pyrimi...)
Affinity DataIC50: 390nMpH: 7.5Assay Description:N-terminally His-tagged PI3K alpha (Cat. No. PV4789; 0.49 mg/ml), Alexa Fluor 647 labeled kinase Tracer 314 (Cat. No. PV6087), Biotin anti-His Tag an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2018
Entry Details
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TargetTarget of rapamycin complex 2 subunit MAPKAP1(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM228130((R)-5-(4-morpholino-5a,6,8,9-tetrahydro-5H- pyrimi...)
Affinity DataIC50: 355nMAssay Description:Inhibition of mTORC2 in human A2058 cells assessed as reduction in PKB phosphorylation at S473 residues incubated for 1 hr by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM228130((R)-5-(4-morpholino-5a,6,8,9-tetrahydro-5H- pyrimi...)
Affinity DataIC50: 524nMAssay Description:Inhibition of mTORC1 in human A2058 cells assessed as reduction in ribosomal protein S6 phosphorylation at Ser235/236 residues incubated for 1 hr by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM228130((R)-5-(4-morpholino-5a,6,8,9-tetrahydro-5H- pyrimi...)
Affinity DataKi:  56nMAssay Description:Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human full-length N-terminal His6-tagged p110alpha/p85alpha expressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed