BDBM227651 6-(5-chloropyridin-3-yl)- 8-[1-fluoro-1-(2- fluorophenyl)ethyl]-7- [(trans-4- methylcyclohexyl)methyl]- 7h-purine-2-carboxylic acid (enantiomer 1)::US9540377, 23.66::US9540377, 23.67

SMILES C[C@H]1CC[C@H](Cn2c(nc3nc(nc(-c4cncc(Cl)c4)c23)C(O)=O)C(C)(F)c2ccccc2F)CC1

InChI Key InChIKey=VKSZBMNCNZFIIR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 227651   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM227651(US9540377, 23.66 | US9540377, 23.67 | 6-(5-chlorop...)
Affinity DataIC50: 5.82nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM227651(US9540377, 23.66 | US9540377, 23.67 | 6-(5-chlorop...)
Affinity DataIC50: 0.176nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In DepthDetails
US Patent