BDBM22734 1,2-bis(3,5-difluorophenyl)ethane-1,2-dione::Benzil-based compound, 12::CHEMBL193229

SMILES Fc1cc(F)cc(c1)C(=O)C(=O)c1cc(F)cc(F)c1

InChI Key InChIKey=ZDXXQKFXZDPNLI-UHFFFAOYSA-N

Data  12 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 22734   

TargetLiver carboxylesterase 1(Rabbit)
University of Mississippi

LigandPNGBDBM22734(CHEMBL193229 | 1,2-bis(3,5-difluorophenyl)ethane-1...)
Affinity DataKi:  17.5nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCocaine esterase(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM22734(CHEMBL193229 | 1,2-bis(3,5-difluorophenyl)ethane-1...)
Affinity DataKi:  23nMAssay Description:Inhibition of human iCE using o-NPA as substrate by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandPNGBDBM22734(CHEMBL193229 | 1,2-bis(3,5-difluorophenyl)ethane-1...)
Affinity DataKi:  23.4nM ΔG°:  -10.4kcal/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCocaine esterase(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM22734(CHEMBL193229 | 1,2-bis(3,5-difluorophenyl)ethane-1...)
Affinity DataKi:  30.6nMAssay Description:Inhibition of human intestinal carboxylesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
University of Mississippi

LigandPNGBDBM22734(CHEMBL193229 | 1,2-bis(3,5-difluorophenyl)ethane-1...)
Affinity DataKi:  73.5nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
University of Mississippi

LigandPNGBDBM22734(CHEMBL193229 | 1,2-bis(3,5-difluorophenyl)ethane-1...)
Affinity DataKi:  74nMAssay Description:Inhibition of human CE1 using o-NPA as substrate by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
University of Mississippi

LigandPNGBDBM22734(CHEMBL193229 | 1,2-bis(3,5-difluorophenyl)ethane-1...)
Affinity DataKi:  74.1nMAssay Description:Inhibition of human carboxylesterase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
University of Mississippi

LigandPNGBDBM22734(CHEMBL193229 | 1,2-bis(3,5-difluorophenyl)ethane-1...)
Affinity DataKi:  97.2nMAssay Description:Inhibition of human carboxylesterase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Mississippi

LigandPNGBDBM22734(CHEMBL193229 | 1,2-bis(3,5-difluorophenyl)ethane-1...)
Affinity DataKi: >1.00E+5nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Mississippi

LigandPNGBDBM22734(CHEMBL193229 | 1,2-bis(3,5-difluorophenyl)ethane-1...)
Affinity DataKi: >1.00E+5nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Mississippi

LigandPNGBDBM22734(CHEMBL193229 | 1,2-bis(3,5-difluorophenyl)ethane-1...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Mississippi

LigandPNGBDBM22734(CHEMBL193229 | 1,2-bis(3,5-difluorophenyl)ethane-1...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human BChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed