BDBM226151 1-(4-Chloro-benzyl)-2,2-diisobutyl-2,3-dihydro-1H-quinazolin-4-one (2af)

SMILES CC(C)CC1(CC(C)C)NC(=O)c2ccccc2N1Cc1ccc(Cl)cc1

InChI Key InChIKey=AIWCEXVSFHVQKB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 226151   

TargetAcetylcholinesterase(Electric eel)
University of Sargodha

LigandPNGBDBM226151(1-(4-Chloro-benzyl)-2,2-diisobutyl-2,3-dihydro-1H-...)
Affinity DataIC50: 600nMpH: 8.0 T: 2°CAssay Description:AChE and BChE inhibitory assay was carried out by following Ellman's methodology [Ellman et al., Biochem. Pharmacol., 7:88-95] using AChE (Electric e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2017
Entry Details

TargetCarboxylic ester hydrolase(Horse)
University of Sargodha

LigandPNGBDBM226151(1-(4-Chloro-benzyl)-2,2-diisobutyl-2,3-dihydro-1H-...)
Affinity DataIC50: 1.56E+3nMpH: 8.0 T: 2°CAssay Description:AChE and BChE inhibitory assay was carried out by following Ellman's methodology [Ellman et al., Biochem. Pharmacol., 7:88-95] using AChE (Electric e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2017
Entry Details

TargetAcetylcholinesterase(Electric eel)
University of Sargodha

LigandPNGBDBM226151(1-(4-Chloro-benzyl)-2,2-diisobutyl-2,3-dihydro-1H-...)
Affinity DataIC50: 600nMAssay Description:Inhibition of electric eel AChE incubated measured after 25 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCholinesterase(Horse)
University of Louisiana At Lafayette

Curated by ChEMBL
LigandPNGBDBM226151(1-(4-Chloro-benzyl)-2,2-diisobutyl-2,3-dihydro-1H-...)
Affinity DataIC50: 1.56E+3nMAssay Description:Inhibition of equine serum BuChE incubated measured after 25 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed