BDBM22561 2-arylbenzimidazole derivative, 7::5-tert-butyl-2-{3-chloro-4-[3-(4-methylpiperazin-1-yl)propoxy]phenyl}-1H-1,3-benzodiazole

SMILES CN1CCN(CCCOc2ccc(cc2Cl)-c2nc3ccc(cc3[nH]2)C(C)(C)C)CC1

InChI Key InChIKey=HOGIQAJOASEATP-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 22561   

TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM22561(5-tert-butyl-2-{3-chloro-4-[3-(4-methylpiperazin-1...)
Affinity DataKi:  65nM ΔG°:  -9.80kcal/molepH: 7.5 T: 2°CAssay Description:The Ki values were calculated based on an experimentally determined appropriate Kd value according to Cheng and Prusoff.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2008
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM22561(5-tert-butyl-2-{3-chloro-4-[3-(4-methylpiperazin-1...)
Affinity DataKi:  65nMAssay Description:Displacement of [3H]histamine from human recombinant histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed