BDBM224214 5-{6-(5- chloropyridin-3-yl)- 7-[(trans-4- methylcyclohexyl) methyl]-8-[(2r,3r)-2- methyl-3- phenylmorpholin-4- yl]-7h-purin-2-yl}- 1,3,4-oxadiazol- 2(3h)-one::US9540377, 16.133

SMILES C[C@H]1CC[C@H](Cn2c(nc3nc(nc(-c4cncc(Cl)c4)c23)-c2n[nH]c(=O)o2)N2CCO[C@H](C)[C@H]2c2ccccc2)CC1

InChI Key InChIKey=MNFALKSWLMSBID-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 224214   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM224214(US9540377, 16.133 | 5-{6-(5- chloropyridin-3-yl)- ...)
Affinity DataIC50: 0.569nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
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US Patent