BDBM22231 (9Z,12Z)-octadeca-9,12-dienoic acid::CHEMBL267476::Linoleic Acid::Linoleic acid (LA)
SMILES CCCCC\C=C/C\C=C/CCCCCCCC(O)=O
InChI Key InChIKey=OYHQOLUKZRVURQ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 43 hits for monomerid = 22231
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]GW2433 from Homo sapiens (human) PPARdelta receptor by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of 8-anilino-1-naphthalene-sulfonic acid from human His-FABP3 expressed in Escherichia coli BL21 (DE3) cells after 3 mins relative to li...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of 8-anilino-1-naphthalene-sulfonic acid from human His-FABP4 expressed in Escherichia coli BL21 (DE3) cells after 3 mins relative to li...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of GST-tagged human VHR using pNpp as substrate after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of GST-tagged human HePTP using pNpp as substrate after 30 minsMore data for this Ligand-Target Pair
TargetSterol O-acyltransferase 1(Rat)
Korea Research Institute of Bioscience and Biotechnology
Curated by ChEMBL
Korea Research Institute of Bioscience and Biotechnology
Curated by ChEMBL
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibitory activity against rat liver microsomal Acyl coenzyme A:cholesterol acyltransferaseMore data for this Ligand-Target Pair
TargetSterol O-acyltransferase 1(Human)
Korea Research Institute of Bioscience and Biotechnology
Curated by ChEMBL
Korea Research Institute of Bioscience and Biotechnology
Curated by ChEMBL
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibitory activity against human Acyl coenzyme A:cholesterol acyltransferase 2More data for this Ligand-Target Pair
TargetSterol O-acyltransferase 1(Human)
Korea Research Institute of Bioscience and Biotechnology
Curated by ChEMBL
Korea Research Institute of Bioscience and Biotechnology
Curated by ChEMBL
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibitory activity against human Acyl coenzyme A:cholesterol acyltransferase 1More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
Affinity DataEC50: 4.80E+3nMAssay Description:Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assa...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Displacement of [3H]GW2331 from Homo sapiens (human) PPARalpha receptor by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.36E+4nMAssay Description:Displacement of 8-anilino-1-naphthalene-sulfonic acid from human His-FABP4 expressed in Escherichia coli BL21 (DE3) cells after 3 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 6.20E+3nMAssay Description:Displacement of [3H]BRL49653 from Homo sapiens (human) PPARgamma receptor by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataKd: 4.80nMAssay Description:Binding affinity to PPAR-alpha (unknown origin) by fluorescence-based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of PPAR-alpha (unknown origin) by SPA assayMore data for this Ligand-Target Pair
Affinity DataEC50: 4.80E+3nMAssay Description:Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 690nMAssay Description:Inhibition of human AKR1C3 expressed in Escherichia coli BL21(DE3) pLysS cells using 9,10-phenanthrenequinone as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 690nMAssay Description:Inhibition of human AKR1C3 expressed in Escherichia coli BL21(DE3) pLysS cells using S-tetralol as substrateMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 4 group A member 2(Human)
Goethe University Frankfurt
Curated by ChEMBL
Goethe University Frankfurt
Curated by ChEMBL
Affinity DataKd: 5.00E+4nMAssay Description:Binding affinity towards Nurr1 ligand binding domain (unknown origin) measured by tryptophan fluorescence spectroscopyMore data for this Ligand-Target Pair
Affinity DataEC50: 1.01E+4nMAssay Description:Agonist activity at human GPR40/Galpha-16 expressed in HEK293 cells by Fluo4-AM dye based intracellular calcium flux assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2.30E+5nMAssay Description:Activation of human SIRT6 deacetylase activity expressed in Escherichia coli BL21(DE3) expressed in Escherichia coli using H3K9Ac peptide substrateMore data for this Ligand-Target Pair
Affinity DataEC50: 1.00E+5nMAssay Description:Activation of recombinant His-tagged SIRT6 (unknown origin) deacetylase activity expressed in Escherichia coli using H3K9Ac peptide substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Allosteric inhibition of soybean LO1More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of pig pancreatic trypsin after 15 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 4.10E+4nMAssay Description:Inhibition of amidolytic activity of human tissue factor/human factor 7aMore data for this Ligand-Target Pair
Affinity DataIC50: 6.50E+4nMAssay Description:Displacement of [3H]DPCPX from rat adenosine A1 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 9.40E+4nMAssay Description:Inhibition of sheep COX2-mediated prostaglandin biosynthesis using [1-14C]arachidonic acidMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+5nMAssay Description:Inhibition of bovine COX1-mediated prostaglandin biosynthesis using [1-14C]arachidonic acidMore data for this Ligand-Target Pair
Affinity DataEC50: 316nMAssay Description:Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of FABP4 (unknown origin) relative to linoleic acidMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of FABP3 (unknown origin) relative to linoleic acidMore data for this Ligand-Target Pair
Affinity DataIC50: 1.77E+4nMAssay Description:Inhibition of FABP4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4.80E+4nMAssay Description:Inhibition of aromatase in human placental microsomes by radiometric methodMore data for this Ligand-Target Pair
Affinity DataEC50: 540nMAssay Description:Agonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataEC50: 540nMAssay Description:Agonist activity at GPR40More data for this Ligand-Target Pair
Affinity DataEC50: 1.80E+3nMAssay Description:Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+4nMAssay Description:Competitive inhibition of soybean LO1More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+4nMAssay Description:Mixed-type inhibition of soybean LO1More data for this Ligand-Target Pair
Affinity DataKi: 1.26E+3nM ΔG°: -8.18kcal/molepH: 8.2 T: 2°CAssay Description:In brief, both wild-type and mutant hFABP5 were expressed and purified to homogeneity as described above and dialyzed in PBS (pH 8.2). Binding affini...More data for this Ligand-Target Pair
Affinity DataKi: 2.17E+3nM ΔG°: -7.85kcal/molepH: 8.2 T: 2°CAssay Description:In brief, both wild-type and mutant hFABP5 were expressed and purified to homogeneity as described above and dialyzed in PBS (pH 8.2). Binding affini...More data for this Ligand-Target Pair
Affinity DataKi: 3.47E+3nM ΔG°: -7.57kcal/molepH: 8.2 T: 2°CAssay Description:In brief, both wild-type and mutant hFABP5 were expressed and purified to homogeneity as described above and dialyzed in PBS (pH 8.2). Binding affini...More data for this Ligand-Target Pair
Affinity DataKi: 6.80E+3nMAssay Description:Displacement of 1,8-ANS from His6-tagged FABP4 (unknown origin) expressed in Escherichia coli BL21(DE3) cells by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 9.30E+3nMAssay Description:Displacement of 1,8-ANS from His6-tagged FABP3 (unknown origin) expressed in Escherichia coli BL21(DE3) cells by fluorescence assayMore data for this Ligand-Target Pair