BDBM22228 (1S,2S)-2-(4-{5-[3-cyano-4-(propan-2-yloxy)phenyl]-1,2,4-oxadiazol-3-yl}-3-methylphenyl)cyclopropane-1-carboxylic acid::3-arylpropionic acid derivative, 18b

SMILES CC(C)Oc1ccc(cc1C#N)-c1nc(no1)-c1ccc(cc1C)[C@H]1C[C@@H]1C(O)=O

InChI Key InChIKey=UTNBQROSKIERML-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 22228   

TargetSphingosine 1-phosphate receptor 1(Human)
Merck Research Laboratories

LigandPNGBDBM22228((1S,2S)-2-(4-{5-[3-cyano-4-(propan-2-yloxy)phenyl]...)
Affinity DataEC50:  0.450nMpH: 7.4 T: 2°CAssay Description:EC50s were determined by measuring the binding of [35S]-GTP-gamma-S to S1P receptors expressed in transfected Chinese hamster ovary (CHO) cell membr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Merck Research Laboratories

LigandPNGBDBM22228((1S,2S)-2-(4-{5-[3-cyano-4-(propan-2-yloxy)phenyl]...)
Affinity DataEC50: >1.00E+4nMpH: 7.4 T: 2°CAssay Description:EC50s were determined by measuring the binding of [35S]-GTP-gamma-S to S1P receptors expressed in transfected Chinese hamster ovary (CHO) cell membr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM22228((1S,2S)-2-(4-{5-[3-cyano-4-(propan-2-yloxy)phenyl]...)
Affinity DataEC50:  13.6nMpH: 7.4 T: 2°CAssay Description:EC50s were determined by measuring the binding of [35S]-GTP-gamma-S to S1P receptors expressed in transfected Chinese hamster ovary (CHO) cell membr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed