BDBM222139 Chymostatin::US11859014, Compound chymostatin

SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)N[C@@H](Cc1ccccc1)C(O)=O)C1CCN=C(N)N1)C(=O)N[C@@H](Cc1ccccc1)C=O

InChI Key InChIKey=MRXDGVXSWIXTQL-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 222139   

TargetChymotrypsinogen A(Bovine)
University of Karachi

LigandPNGBDBM222139(Chymostatin | US11859014, Compound chymostatin)
Affinity DataIC50: 5.80E+3nMpH: 7.6Assay Description:The α-chymotrypsin inhibition activity was evaluated in 50 mM Tris-HCl buffer pH 7.6 with 10 mM CaCl2. α-Chymotrypsin (bovine pancreas) at ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2017
Entry Details Article
PubMed
TargetGenome polyprotein(Norovirus Hu/GII.P4_GII.4/Minerva)
Emory University

US Patent
LigandPNGBDBM222139(Chymostatin | US11859014, Compound chymostatin)
Affinity DataIC50: 1.37E+4nMAssay Description:The ability of these compounds to inhibit the NoV, specifically Minerva virus protease catalytic Cys139 covalently (IC50 and Ki) was determined with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2024
Entry Details
Go to US Patent

TargetGenome polyprotein(Norovirus Hu/GII.P4_GII.4/Minerva)
Emory University

US Patent
LigandPNGBDBM222139(Chymostatin | US11859014, Compound chymostatin)
Affinity DataKi:  1.60E+3nMAssay Description:The ability of these compounds to inhibit the NoV, specifically Minerva virus protease catalytic Cys139 covalently (IC50 and Ki) was determined with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2024
Entry Details
Go to US Patent

TargetChymotrypsinogen A(Bovine)
University of Karachi

LigandPNGBDBM222139(Chymostatin | US11859014, Compound chymostatin)
Affinity DataKi:  2.60E+3nMAssay Description:The change in optical density per minute (OD/min) was obtained by incorporating various concentrations of compounds over a range of substrate (SPpNA)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2017
Entry Details Article
PubMed