BDBM222128 7-Chloro-2-(2-fluorophenyl)-4H-3,1-benzoxazin-4-one (17)

SMILES Fc1ccccc1-c1nc2cc(Cl)ccc2c(=O)o1

InChI Key InChIKey=PIWZORMCGSCBSX-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 222128   

TargetChymotrypsinogen A(Bovine)
University of Karachi

LigandPNGBDBM222128(7-Chloro-2-(2-fluorophenyl)-4H-3,1-benzoxazin-4-on...)
Affinity DataIC50: 3.29E+5nMpH: 7.6Assay Description:The α-chymotrypsin inhibition activity was evaluated in 50 mM Tris-HCl buffer pH 7.6 with 10 mM CaCl2. α-Chymotrypsin (bovine pancreas) at ...More data for this Ligand-Target Pair
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PubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Human)
Russian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM222128(7-Chloro-2-(2-fluorophenyl)-4H-3,1-benzoxazin-4-on...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of nuclease activity of APE1 in human glioblastoma cells assessed as reduction in AP site DNA cleavageMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetChymotrypsinogen A(Bovine)
University of Karachi

LigandPNGBDBM222128(7-Chloro-2-(2-fluorophenyl)-4H-3,1-benzoxazin-4-on...)
Affinity DataKi:  3.03E+5nMAssay Description:The change in optical density per minute (OD/min) was obtained by incorporating various concentrations of compounds over a range of substrate (SPpNA)...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed