BDBM222078 6-Chloro-3-((2-(2,4-dichlorophenyl)imidazo[1,2-a]pyridin-8-yl)methoxy)-[1,2,4]triazolo[4,3-b] pyridazine (7g)

SMILES Clc1ccc(-c2cn3cccc(COc4nnc5ccc(Cl)nn45)c3n2)c(Cl)c1

InChI Key InChIKey=QJQFWXRUJUNRHW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 222078   

TargetEpidermal/Hepatocyte growth factor receptor(Human)
China Pharmaceutical University

LigandPNGBDBM222078(6-Chloro-3-((2-(2,4-dichlorophenyl)imidazo[1,2-a]p...)
Affinity DataIC50: 1.42E+4nMAssay Description:The c-Met kinase activity as tested with enzyme-linked immunosorbent assays (ELISAs) as previously reported protocol [Qiang et al., Bioorg. Med. Chem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase/Hepatocyte growth factor receptor(Human)
China Pharmaceutical University

LigandPNGBDBM222078(6-Chloro-3-((2-(2,4-dichlorophenyl)imidazo[1,2-a]p...)
Affinity DataIC50: 1.13E+4nMAssay Description:The c-Met kinase activity as tested with enzyme-linked immunosorbent assays (ELISAs) as previously reported protocol [Qiang et al., Bioorg. Med. Chem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2017
Entry Details Article
PubMed
LigandPNGBDBM222078(6-Chloro-3-((2-(2,4-dichlorophenyl)imidazo[1,2-a]p...)
Affinity DataIC50: 1.22E+4nMAssay Description:The c-Met kinase activity as tested with enzyme-linked immunosorbent assays (ELISAs) as previously reported protocol [Qiang et al., Bioorg. Med. Chem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2017
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Nirma University

Curated by ChEMBL
LigandPNGBDBM222078(6-Chloro-3-((2-(2,4-dichlorophenyl)imidazo[1,2-a]p...)
Affinity DataIC50: 53nMAssay Description:Inhibition of c-Met (unknown origin) kinase activity using peptide as substrate in presence of ATP incubated for 1 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed