BDBM221997 4-[3-(4-Bromo-phenyl)-5-(3,4,5-trimethoxy-phenyl)-4,5-dihydropyrazol- 1-yl]-benzene-sulfonamide (10a)

SMILES COc1cc(cc(OC)c1OC)C1CC(=NN1c1ccc(cc1)S(N)(=O)=O)c1ccc(Br)cc1

InChI Key InChIKey=DOSNORRGQWDFAU-UHFFFAOYSA-N

Data  4 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 221997   

TargetProstaglandin G/H synthase 2(Sheep)
Beni-Suef University

LigandPNGBDBM221997(4-[3-(4-Bromo-phenyl)-5-(3,4,5-trimethoxy-phenyl)-...)
Affinity DataIC50: 780nMAssay Description:The in vitro inhibition of ovine COX-1 and COX-2 was measured using an enzyme immuno assay (EIA) kit (Cayman Chemical, Ann Arbor, MI, USA) according ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Beni-Suef University

LigandPNGBDBM221997(4-[3-(4-Bromo-phenyl)-5-(3,4,5-trimethoxy-phenyl)-...)
Affinity DataIC50: 7.52E+3nMAssay Description:The in vitro inhibition of ovine COX-1 and COX-2 was measured using an enzyme immuno assay (EIA) kit (Cayman Chemical, Ann Arbor, MI, USA) according ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM221997(4-[3-(4-Bromo-phenyl)-5-(3,4,5-trimethoxy-phenyl)-...)
Affinity DataKi:  0.0890nMAssay Description:Binding affinity to human recombinant CA2 assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCarbonic anhydrase 12(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM221997(4-[3-(4-Bromo-phenyl)-5-(3,4,5-trimethoxy-phenyl)-...)
Affinity DataKi: >9nMAssay Description:Binding affinity to human recombinant CA12 assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCarbonic anhydrase 9(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM221997(4-[3-(4-Bromo-phenyl)-5-(3,4,5-trimethoxy-phenyl)-...)
Affinity DataKi: >44nMAssay Description:Binding affinity to human recombinant CA9 assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM221997(4-[3-(4-Bromo-phenyl)-5-(3,4,5-trimethoxy-phenyl)-...)
Affinity DataKi: >230nMAssay Description:Binding affinity to human recombinant CA1 assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed