BDBM22172 (2S)-1-{4-[2-(diphenylmethoxy)ethyl]piperazin-1-yl}-3-phenylpropan-2-ol::CHEMBL28149::GBR 12935 Analogue, (S)-6

SMILES O[C@H](CN1CCN(CCOC(c2ccccc2)c2ccccc2)CC1)Cc1ccccc1

InChI Key InChIKey=ZZHKHRXDQLQSFW-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 22172   

TargetSodium-dependent dopamine transporter(Rat)
National Taiwan University

LigandPNGBDBM22172(CHEMBL28149 | (2S)-1-{4-[2-(diphenylmethoxy)ethyl]...)
Affinity DataKi:  2.30nM ΔG°:  -10.9kcal/molepH: 7.4 T: 2°CAssay Description:The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2008
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Taiwan University

LigandPNGBDBM22172(CHEMBL28149 | (2S)-1-{4-[2-(diphenylmethoxy)ethyl]...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity for dopamine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM22172(CHEMBL28149 | (2S)-1-{4-[2-(diphenylmethoxy)ethyl]...)
Affinity DataKi:  2.16E+3nMAssay Description:Binding affinity for serotonin transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM22172(CHEMBL28149 | (2S)-1-{4-[2-(diphenylmethoxy)ethyl]...)
Affinity DataKi:  2.20E+3nM ΔG°:  -7.17kcal/molepH: 7.4 T: 2°CAssay Description:The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2008
Entry Details Article
PubMed