BDBM22167 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine::CHEMBL26320::CHEMBL434080::GBR 12935::GBR-12935

SMILES C(CN1CCN(CCOC(c2ccccc2)c2ccccc2)CC1)Cc1ccccc1

InChI Key InChIKey=RAQPOZGWANIDQT-UHFFFAOYSA-N

Data  25 KI  19 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 44 hits for monomerid = 22167   

TargetSodium-dependent serotonin transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataIC50: 623nMAssay Description:Binding affinity was determined at the Serotonin transporter labeled with radioligand [125 I] RTI-55More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataIC50: 290nMAssay Description:Compound was tested for its ability to inhibit the neurotransmitter serotonin-5-HT reuptake system using [3H]5-HT as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2012
Entry Details Article

LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataIC50: 37nMAssay Description:Compound was tested for its ability to inhibit the neurotransmitter dopamine-DA reuptake system using [3H]dopamine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2012
Entry Details Article

TargetSodium-dependent serotonin transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataIC50: 289nMAssay Description:Inhibition of [3H]5-HT reuptake at rat serotonin transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of dopamine DA reuptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataIC50: 17nMAssay Description:Binding affinity against sigma receptor using radioligand ([3H](+)-pentazocine) binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataIC50: 298nMAssay Description:Reuptake inhibition of [3H]-5-HT (5-HT) in rat.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataIC50: 3.70nMAssay Description:Reuptake inhibition of [3H]-labeled dopamine (DA) in rat.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataIC50: 3.71E+3nMAssay Description:Inhibition of [3H]5-HT reuptake in HEK293 cells expressing human serotonin transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataIC50: 1.26E+3nMAssay Description:Compound was tested for its ability to inhibit the uptake of Norepinephrine in Norepinephrine transporter systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataIC50: 3.70nMAssay Description:Compound was tested for its ability to inhibit the uptake of [3H]dopamine in DAT (dopamine transporter system) expressing cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataIC50: 289nMAssay Description:Compound was tested for its ability to inhibit the uptake of Serotonin in Serotonin transporter systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataIC50: 17nMAssay Description:Sigma receptor binding was determined by labeling with radioligand [3H](+)-pentazocine on frozen membranes obtained from frozen guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataIC50: 3.70nMAssay Description:Binding affinity at the dopamine transporter using [125I]RTI-55 in rat caudate membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataIC50: 3.70nMAssay Description:Reuptake inhibition at the dopamine transporter labeled with radioligand [3H]dopamine on synaptosomes obtained from rat caudate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataIC50: 298nMAssay Description:Reuptake inhibition at the dopamine transporter labeled with radioligand [3H]-5-HT on synaptosomes obtained from whole rat brain minus cerebellum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataIC50: 4.10nMAssay Description:Binding against Dopamine transporter using radioligand as [3H]GBR 12935More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataIC50: 18nMAssay Description:Inhibition of [3H]dopamine reuptake in HEK293 cells expressing human dopamine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataIC50: 165nMAssay Description:Inhibition of [3H]NE reuptake by human norepinephrine transporter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2012
Entry Details Article
PubMed
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataKi:  0.420nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details
PubMed
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataKi:  0.760nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details
PubMed
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataKi:  1.18nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details
PubMed
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataKi:  1.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2012
Entry Details
PubMed
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataKi:  2.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataKi:  3.70nM ΔG°:  -10.7kcal/molepH: 7.4 T: 2°CAssay Description:The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2008
Entry Details Article
PubMed
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataKi:  3.70nMAssay Description:Binding affinity for dopamine transporter (DAT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataKi:  3.70nMAssay Description:Binding affinity towards dopamine transporter (DAT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataKi:  3.70nMAssay Description:Binding affinity for dopamine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataKi:  3.70nMAssay Description:Binding affinity against dopamine transporter labelled with [125I]- RTI-55 in rat.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataKi:  3.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details Article
PubMed
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataKi:  3.70nMAssay Description:Binding affinity against Dopamine transporter using [125]RTI-55More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataKi:  13nMAssay Description:Binding affinity to dopamine transporter (DAT) using [3H]WIN-35428 as a radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataKi:  73nMAssay Description:Inhibition of [125I]RTI-55 binding to dopamine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2012
Entry Details Article
PubMed
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataKi:  277nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataKi:  289nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataKi:  620nMAssay Description:Binding affinity for serotonin transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataKi:  620nMAssay Description:Binding affinity against serotonin transporter using [125]RTI-55More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataKi:  620nM ΔG°:  -7.87kcal/molepH: 7.4 T: 2°CAssay Description:The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2008
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataKi:  623nMAssay Description:Binding affinity for serotonin transporter (SERT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataKi:  623nMAssay Description:Binding affinity towards rat serotonin transporter (SERT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataKi:  623nMAssay Description:Binding affinity against Serotonin transporter (SERT) labelled with [125I]RTI-55 in rat.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataKi:  630nMAssay Description:Binding affinity at the norepinephrine transporter was measured using [125I]RTI-55 as a radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataKi:  2.09E+3nMAssay Description:Binding affinity for serotonin transporter using [125I]RTI-55More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Mouse)
National Institutes of Health

Curated by PDSP Ki Database
LigandPNGBDBM22167(GBR-12935 | CHEMBL26320 | CHEMBL434080 | 1-[2-(dip...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2012
Entry Details Article
PubMed