BDBM221073 SPHINX scaffold, 3::US9695160, SPHINX7::US9796707, Reference Compound SPHINX7

SMILES CN(C)CCN1CCN(CC1)c1ccc(cc1NC(=O)c1ccc(o1)-c1ccncc1)C(F)(F)F

InChI Key InChIKey=ALLIMXLDTJFWHR-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 221073   

TargetSRSF protein kinase 1(Human)
Exonate

LigandPNGBDBM221073(US9695160, SPHINX7 | SPHINX scaffold, 3 | US979670...)
Affinity DataIC50: 59nMpH: 7.5 T: 2°CAssay Description:A reaction buffer containing 200 mM Tris pH 7.5, 100 mM MgCl2 and 0.1 mg/ml BSA was added to 43 μM SRSF1Arg-Ser (RS) peptide (NH2-RSPSYGRSRSRSRS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2017
Entry Details Article
PubMed
LigandPNGBDBM221073(US9695160, SPHINX7 | SPHINX scaffold, 3 | US979670...)
Affinity DataIC50: 36nMpH: 7.45 T: 2°CAssay Description:Whole cell patch clamp recordings of hERG current (IhERG) were made at 37 °C from human embryonic kidney cells (HEK 293) cells stably expressing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2017
Entry Details Article
PubMed
TargetSRSF protein kinase 1(Human)
Exonate

LigandPNGBDBM221073(US9695160, SPHINX7 | SPHINX scaffold, 3 | US979670...)
Affinity DataIC50: 55nMT: 2°CAssay Description:Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2018
Entry Details
Go to US Patent

TargetSRSF protein kinase 1(Human)
Exonate

LigandPNGBDBM221073(US9695160, SPHINX7 | SPHINX scaffold, 3 | US979670...)
Affinity DataIC50: 54.7nMAssay Description:Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
Go to US Patent

TargetSRSF protein kinase 1(Human)
Exonate

LigandPNGBDBM221073(US9695160, SPHINX7 | SPHINX scaffold, 3 | US979670...)
Affinity DataIC50: 59nMAssay Description:Inhibition of SRPK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed