BDBM2123 1-(5-bromopyridin-2-yl)-3-[2-(2,6-difluoro-3-methoxyphenyl)ethyl]thiourea::LY300046HCl Analog 7::N-[2-(2,6-Difluoro-3-methoxyphenethyl)]-N-[2-(5-bromopyridyl)]thiourea::PETT deriv.

SMILES COc1ccc(F)c(CCNC(=S)Nc2ccc(Br)cn2)c1F

InChI Key InChIKey=HINMFTUIHCBZCY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 2123   

TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Eli Lilly

LigandPNGBDBM2123(N-[2-(2,6-Difluoro-3-methoxyphenethyl)]-N-[2-(5-br...)
Affinity DataIC50: 6nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandPNGBDBM2123(N-[2-(2,6-Difluoro-3-methoxyphenethyl)]-N-[2-(5-br...)
Affinity DataIC50: 870nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C](Human immunodeficiency virus type 1)
Eli Lilly

LigandPNGBDBM2123(N-[2-(2,6-Difluoro-3-methoxyphenethyl)]-N-[2-(5-br...)
Affinity DataIC50: 60nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed