BDBM209924 PKUMDL-WQ-2101::US10722489, Compound PKUMDL-WL-2101

SMILES Oc1ccc(C(=O)N\N=C\c2cc(ccc2O)[N+]([O-])=O)c(O)c1

InChI Key InChIKey=OXONIXZPWKJHMW-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 209924   

TargetD-3-phosphoglycerate dehydrogenase(Human)
Peking University

LigandPNGBDBM209924(PKUMDL-WQ-2101 | US10722489, Compound PKUMDL-WL-21...)
Affinity DataIC50: 3.48E+4nMpH: 7.1Assay Description:To evaluate the effects of compounds on PHGDH activity, compounds were first pre-incubated with enzyme samples in the assay buffer (25 mM HEPES, pH 7...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2017
Entry Details Article
PubMed
TargetD-3-phosphoglycerate dehydrogenase [3-314](Human)
Peking University

LigandPNGBDBM209924(PKUMDL-WQ-2101 | US10722489, Compound PKUMDL-WL-21...)
Affinity DataIC50: 3.01E+4nMpH: 7.1Assay Description:To evaluate the effects of compounds on PHGDH activity, compounds were first pre-incubated with enzyme samples in the assay buffer (25 mM HEPES, pH 7...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2017
Entry Details Article
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Peking University

LigandPNGBDBM209924(PKUMDL-WQ-2101 | US10722489, Compound PKUMDL-WL-21...)
Affinity DataIC50: 4.49E+4nMpH: 7.1Assay Description:To evaluate the effects of compounds on PHGDH activity, compounds were first pre-incubated with enzyme samples in the assay buffer (25 mM HEPES, pH 7...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2017
Entry Details Article
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Peking University

LigandPNGBDBM209924(PKUMDL-WQ-2101 | US10722489, Compound PKUMDL-WL-21...)
Affinity DataIC50: 560nMpH: 7.4Assay Description:The binding affinities of compounds towards PHGDH were assayed using the SPR-based Biacore T200 instrument (GE Healthcare). PHGDH was immobilized on ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2017
Entry Details Article
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Peking University

LigandPNGBDBM209924(PKUMDL-WQ-2101 | US10722489, Compound PKUMDL-WL-21...)
Affinity DataIC50: 3.48E+4nMAssay Description:Inhibition of PHGDH (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2020
Entry Details Article
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Peking University

LigandPNGBDBM209924(PKUMDL-WQ-2101 | US10722489, Compound PKUMDL-WL-21...)
Affinity DataIC50: 3.48E+4nMAssay Description:The activity of recombinant PHGDH was measured by monitoring the reduced nicotinamideadenine dinucleotide (NADH) to nicotinamideadenine dinucleotide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2021
Entry Details
Go to US Patent

TargetD-3-phosphoglycerate dehydrogenase(Human)
Peking University

LigandPNGBDBM209924(PKUMDL-WQ-2101 | US10722489, Compound PKUMDL-WL-21...)
Affinity DataIC50: 3.48E+4nMAssay Description:Inhibition of human full-length PHGDH incubated for 10 mins by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed