BDBM209909 US9273014, Comparative Compound 45::US9427442, Comparative Compound 26

SMILES CCC[C@@H]([C@@H](CC(C)C)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O)C(N)=O

InChI Key InChIKey=RTMFXQXENIODOP-UHFFFAOYSA-N

Data  1 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 209909   

LigandPNGBDBM209909(US9273014, Comparative Compound 45 | US9427442, Co...)
Affinity DataIC50: 64.1nMAssay Description:The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2017
Entry Details
Go to US Patent

LigandPNGBDBM209909(US9273014, Comparative Compound 45 | US9427442, Co...)
Affinity DataIC50: 48.3nMAssay Description:The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2017
Entry Details
Go to US Patent

LigandPNGBDBM209909(US9273014, Comparative Compound 45 | US9427442, Co...)
Affinity DataIC50: 64.1nMAssay Description:The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
Go to US Patent

LigandPNGBDBM209909(US9273014, Comparative Compound 45 | US9427442, Co...)
Affinity DataIC50: 48.3nMAssay Description:The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
Go to US Patent

TargetPresenilin-1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM209909(US9273014, Comparative Compound 45 | US9427442, Co...)
Affinity DataIC50: 6.40nMAssay Description:Displacement of [3H]IN973 from gamma-secretase in human THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM209909(US9273014, Comparative Compound 45 | US9427442, Co...)
Affinity DataIC50: 1.06E+3nMAssay Description:Displacement of [3H]L685458 from gamma-secretase in human THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM209909(US9273014, Comparative Compound 45 | US9427442, Co...)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]succinamide from gamma secretase in THP1 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed