BDBM20973 8-[butyl(ethyl)amino]-4-(4-methoxy-2-methylphenyl)-6-methyl-1H,2H,3H,4H-pyrido[2,3-b]pyrazin-2-one::CHEMBL189089::Pyridopyrazinone, 1a

SMILES CCCCN(CC)c1cc(C)nc2N(CC(=O)Nc12)c1ccc(OC)cc1C

InChI Key InChIKey=LYSNALHFMZZUFA-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 20973   

TargetCorticotropin-releasing factor receptor 1(Rat)
Bristol-Myers Squibb

LigandPNGBDBM20973(CHEMBL189089 | 8-[butyl(ethyl)amino]-4-(4-methoxy-...)
Affinity DataIC50: 0.920nMpH: 7.0 T: 2°CAssay Description:The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro. More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Rat)
Bristol-Myers Squibb

LigandPNGBDBM20973(CHEMBL189089 | 8-[butyl(ethyl)amino]-4-(4-methoxy-...)
Affinity DataIC50: 0.920nMAssay Description:Inhibition of [125I]ovine-CRF binding to corticotropin releasing factor receptor 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Emory University

Curated by ChEMBL
LigandPNGBDBM20973(CHEMBL189089 | 8-[butyl(ethyl)amino]-4-(4-methoxy-...)
Affinity DataKi:  4nMAssay Description:Displacement of [125I]-Tyr0-sauvagine from human CRF1 receptor expressed in HEK293T cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed