BDBM209472 US10328074, Example III-13::US11077107, Example III-13::US9266891, III-13

SMILES CNc1nc(cn2c(C)nnc12)-c1nc2ccc(cc2n1Cc1ccccc1)N1CCN(C)CC1

InChI Key InChIKey=JLUUVUUYIXBDCG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 209472   

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209472(US9266891, III-13 | US10328074, Example III-13 | U...)
Affinity DataIC50: 9nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209472(US9266891, III-13 | US10328074, Example III-13 | U...)
Affinity DataIC50: 9nMAssay Description:This assay is used to determine whether the compounds inhibit the interaction between the first (BRD4-BD1) or the second (BRD4-BD2) bromodomain of BR...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM209472(US9266891, III-13 | US10328074, Example III-13 | U...)
Affinity DataIC50: 9nMAssay Description:Displacement of biotinylated tetra-acetylated histone H4 peptide from GST-tagged BRD4-BD1 (44 to 168 residues) (unknown origin) measured after 30 min...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM209472(US9266891, III-13 | US10328074, Example III-13 | U...)
Affinity DataIC50: 9nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...More data for this Ligand-Target Pair
In DepthDetails
US Patent