BDBM208981 (4R,4aR,7S,7aR,12bS)-3-methyl-2,3,4,4a,7,7a-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol::US9233167, Morphine

SMILES CO[C@H]1C=CC2C3Cc4ccc(O)c5OC1[C@]2(CCN3C)c45

InChI Key InChIKey=FNAHUZTWOVOCTL-UHFFFAOYSA-N

Data  3 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 208981   

TargetMu-type opioid receptor(Human)
Nektar Therapeutics

US Patent
LigandPNGBDBM208981(US9233167, Morphine | (4R,4aR,7S,7aR,12bS)-3-methy...)
Affinity DataEC50:  28.5nMT: 2°CAssay Description:Briefly, suspensions of cells expressing either the mu, kappa or delta opioid receptors were prepared in buffer containing 0.5 mM isobutyl-methyl xan...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetKappa-type opioid receptor(Human)
Nektar Therapeutics

US Patent
LigandPNGBDBM208981(US9233167, Morphine | (4R,4aR,7S,7aR,12bS)-3-methy...)
Affinity DataEC50:  624nMT: 2°CAssay Description:Briefly, suspensions of cells expressing either the mu, kappa or delta opioid receptors were prepared in buffer containing 0.5 mM isobutyl-methyl xan...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMu-type opioid receptor(Human)
Nektar Therapeutics

US Patent
LigandPNGBDBM208981(US9233167, Morphine | (4R,4aR,7S,7aR,12bS)-3-methy...)
Affinity DataKi:  8.44nM ΔG°:  -11.0kcal/moleT: 2°CAssay Description:Briefly, serial dilutions of the test compounds were placed in a 96-well plate to which were added SPA beads, membrane and radioligand. The assay con...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetKappa-type opioid receptor(Human)
Nektar Therapeutics

US Patent
LigandPNGBDBM208981(US9233167, Morphine | (4R,4aR,7S,7aR,12bS)-3-methy...)
Affinity DataKi:  118nM ΔG°:  -9.44kcal/moleT: 2°CAssay Description:Briefly, serial dilutions of the test compounds were placed in a 96-well plate to which were added SPA beads, membrane and radioligand. The assay con...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDelta-type opioid receptor(Human)
Nektar Therapeutics

US Patent
LigandPNGBDBM208981(US9233167, Morphine | (4R,4aR,7S,7aR,12bS)-3-methy...)
Affinity DataKi:  4.30E+3nM ΔG°:  -7.32kcal/moleT: 2°CAssay Description:Briefly, serial dilutions of the test compounds were placed in a 96-well plate to which were added SPA beads, membrane and radioligand. The assay con...More data for this Ligand-Target Pair
In DepthDetails
US Patent