BDBM207985 4,5-di(4-chlorobenzyl)-3-(6-chloro-1H-indol-3-yl)-5-hydroxy-1,5-dihydro-2H-furan-2-one (2b)

SMILES OC1(Cc2ccc(Cl)cc2)OC(=O)C(=C1Cc1ccc(Cl)cc1)c1c[nH]c2cc(Cl)ccc12

InChI Key InChIKey=MQUDOLGFLXRQKO-UHFFFAOYSA-N

Data  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 207985   

TargetE3 ubiquitin-protein ligase Mdm2 [1-118](Human)
Jagiellonian University

LigandPNGBDBM207985(4,5-di(4-chlorobenzyl)-3-(6-chloro-1H-indol-3-yl)-...)
Affinity DataKd:  8.60E+4nMpH: 7.4 T: 2°CAssay Description:Uniform 15N isotope labeling was achieved by expression of the protein in the M9 minimal media containing 15NH4Cl as the sole nitrogen source. The fi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2 [1-118,T47W](Human)
Jagiellonian University

LigandPNGBDBM207985(4,5-di(4-chlorobenzyl)-3-(6-chloro-1H-indol-3-yl)-...)
Affinity DataKd:  1.50E+3nMpH: 7.4 T: 2°CAssay Description:MST (NanoTemper Technologies GmbH) was used to determine the binding affinities between Mdm2 (residues 1-118 T47W; 500 nM) and inhibitors. T47W mutat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed