BDBM207586 US10501467, Example 31::US9260440, 31::US9617273, Example 31

SMILES CC1(C)Cc2n(CCN3CCCCC3)c3cccc4c3c2c(C1)n[nH]c4=O

InChI Key InChIKey=LNWPRZVIPZXIHL-UHFFFAOYSA-N

Data  14 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 207586   

TargetPoly [ADP-ribose] polymerase 1(Human)
Beigene

US Patent
LigandPNGBDBM207586(US9260440, 31 | US9617273, Example 31 | US10501467...)
Affinity DataIC50: 2.90nMpH: 8.0Assay Description:PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Beigene

US Patent
LigandPNGBDBM207586(US9260440, 31 | US9617273, Example 31 | US10501467...)
Affinity DataIC50: 0.200nMAssay Description:PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details
Go to US Patent

LigandPNGBDBM207586(US9260440, 31 | US9617273, Example 31 | US10501467...)
Affinity DataIC50: 2.00E+4nMAssay Description:PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Beigene

US Patent
LigandPNGBDBM207586(US9260440, 31 | US9617273, Example 31 | US10501467...)
Affinity DataIC50: 700nMAssay Description:Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Beigene

US Patent
LigandPNGBDBM207586(US9260440, 31 | US9617273, Example 31 | US10501467...)
Affinity DataIC50: 2.90E+3nMAssay Description:PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Beigene

US Patent
LigandPNGBDBM207586(US9260440, 31 | US9617273, Example 31 | US10501467...)
Affinity DataIC50: 200nMAssay Description:PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Beigene

US Patent
LigandPNGBDBM207586(US9260440, 31 | US9617273, Example 31 | US10501467...)
Affinity DataIC50: 2.00E+7nMAssay Description:PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Beigene

US Patent
LigandPNGBDBM207586(US9260440, 31 | US9617273, Example 31 | US10501467...)
Affinity DataIC50: 7.00E+5nMAssay Description:Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Beigene

US Patent
LigandPNGBDBM207586(US9260440, 31 | US9617273, Example 31 | US10501467...)
Affinity DataIC50: 2.90E+3nMAssay Description:PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Beigene

US Patent
LigandPNGBDBM207586(US9260440, 31 | US9617273, Example 31 | US10501467...)
Affinity DataIC50: 200nMAssay Description:PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent

TargetProtein mono-ADP-ribosyltransferase PARP3(Human)
Beigene

US Patent
LigandPNGBDBM207586(US9260440, 31 | US9617273, Example 31 | US10501467...)
Affinity DataIC50: 2.00E+7nMAssay Description:PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Beigene

US Patent
LigandPNGBDBM207586(US9260440, 31 | US9617273, Example 31 | US10501467...)
Affinity DataIC50: 7.00E+5nMAssay Description:Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Beigene

US Patent
LigandPNGBDBM207586(US9260440, 31 | US9617273, Example 31 | US10501467...)
Affinity DataEC50:  3.20nMAssay Description:Inhibition of PARP-1 in human HeLa cells incubated for 18 hrs in presence of H2O2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
Beigene

US Patent
LigandPNGBDBM207586(US9260440, 31 | US9617273, Example 31 | US10501467...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of PARP-2 (unknown origin) pre-incubated for 30 mins before addition of activated DNA and NAD by chemiluminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Beigene

US Patent
LigandPNGBDBM207586(US9260440, 31 | US9617273, Example 31 | US10501467...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human PARP-1 catalytic domain (662 to 1011 residues) expressed in Escherichia coli BL21(DE3) cells pre-incubated for 30 mins before add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed