BDBM206337 3-methoxy-2- ({(3r,6r)-6-methyl-1- [(2-pyrimidin-2- ylthiophen-3- yl)carbonyl]piperidin- 3-yl}oxy)pyridine-4- carbonitrile::US9546152, example 108

SMILES COc1c(O[C@@H]2CC[C@@H](C)N(C2)C(=O)c2ccsc2-c2ncccn2)nccc1C#N

InChI Key InChIKey=VUPCSJNTEFJWTF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 206337   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM206337(US9546152, example 108 | 3-methoxy-2- ({(3r,6r)-6-...)
Affinity DataIC50: 14nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM206337(US9546152, example 108 | 3-methoxy-2- ({(3r,6r)-6-...)
Affinity DataIC50: 713nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent